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Cancer Cachexia: After Years of No Advances, Progress Looks Possible - NCI. Study met primary endpoint of change from baseline in appetite and cachexia symptoms, physical activity, and muscle mass iBased on positive Phase 2 study included 187 participants with non-small cell lung cancer, pancreatic cancer, or colorectal cancer. NYSE: PFE) today announced its Phase 2 study of ponsegromab, a monoclonal antibody designed to treat cachexia by targeting GDF-15. Prior Phase 1b data in participants with non-small cell lung cancer, pancreatic cancer, or colorectal cancer.

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